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Dec1 and Dec2 are regulators of the mammalian molecular clock

Honma, Ken-ichi

  1. Moore, R. Y. & Eichler, V. B. Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res. 42, 201–206 (1972)

    Article  CAS  Google Scholar 

  2. Stephan, F. & Zucker, I. Circadian rhythms in drinking behavior and locomotor activity are eliminated by suprachiasmatic lesions. Proc. Natl Acad. Sci. USA 54, 1521–1527 (1972)

    Google Scholar 

  3. Reppert, S. M. & Wever, D. R. Molecular analysis of mammalian circadian rhythms. Annu. Rev. Physiol. 63, 647–676 (2001)

    Article  CAS  Google Scholar 

  4. Gekakis, N. et al. Role of the CLOCK protein in the mammalian circadian mechanism. Science 280, 1564–1569 (1998)

    Article  ADS  CAS  Google Scholar 

  5. Darlington, T. K. et al. Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science 280, 1599–1600 (1998)

    Article  ADS  CAS  Google Scholar 

  6. Kume, K. et al. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98, 193–205 (1999)

    Article  CAS  Google Scholar 

  7. Yagita, K. et al. Dimerization and nuclear entry of mPER proteins in mammalian cells. Gene Dev. 14, 1353–1363 (2000)

    CAS  PubMed  Google Scholar 

  8. Dunlap, J. C. Molecular bases for circadian clocks. Cell 96, 271–290 (1999)

    Article  CAS  Google Scholar 

  9. Shearman, L. P. et al. Interacting molecular loops in the mammalian circadian clock. Science 288, 1013–1019 (2000)

    Article  ADS  CAS  Google Scholar 

  10. Yu, W., Nomura, M. & Ikeda, M. Interacting feedback loop within the mammalian clock: BMAL1 is negatively autoregulated and upregulated by CRY1, CRY2, and PER2. Biochem. Biophys. Res. Commun. 290, 933–941 (2002)

    Article  CAS  Google Scholar 

  11. Shen, M. et al. Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes. Biochem. Biophys. Res. Commun. 236, 294–298 (1997)

    Article  CAS  Google Scholar 

  12. Boudjelal, M. et al. Overexpression of Stra 13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. Gene Dev. 11, 2052–2065 (1997)

    Article  CAS  Google Scholar 

  13. Rossner, M. J. et al. SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation. Mol. Cell. Neurosci. 9, 460–475 (1997)

    Article  CAS  Google Scholar 

  14. Fujimoto, K. et al. Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins. Biochem. Biophys. Res. Commun. 280, 164–171 (2001)

    Article  CAS  Google Scholar 

  15. Teramoto, M. et al. Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1·Stra13·SHARP-2/BHLHB2. J. Biochem. (Tokyo) 129, 391–396 (2001)

    Article  CAS  Google Scholar 

  16. Dear, T. N. et al. Identification of interaction partners for the basic-helix-loop-helix protein E47. Oncogene 14, 891–898 (1997)

    Article  CAS  Google Scholar 

  17. Kallio, P. J. et al. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J. Biol. Chem. 274, 6519–6525 (1999)

    Article  CAS  Google Scholar 

  18. Mitsui, S. et al. Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism. Genes Dev. 15, 995–1006 (2001)

    Article  CAS  Google Scholar 

  19. Moore, R. Y. & Card, J. P. Visual pathways and the entrainment of circadian rhythms. Ann. NY Acad. Sci. 453, 123–133 (1985)

    Article  ADS  CAS  Google Scholar 

  20. Honma, K., Honma, S. & Hiroshige, T. Response curve, free-running period, and activity time in circadian locomotor rhythm of rats. Jpn J. Physiol. 35, 643–658 (1985)

    Article  CAS  Google Scholar 

  21. Honma, S. et al. Circadian oscillation of BMAL1, a partner of a mammalian clock gene Clock in rat suprachiasmatic nucleus. Biochem. Biophys. Res. Commun. 250, 83–87 (1998)

    Article  CAS  Google Scholar 

  22. Masubuchi, S. et al. Clock genes outside the suprachiasmatic nucleus involved in manifestation of locomotor activity rhythm in rats. Eur. J. Neurosci. 12, 4206–4214 (2000)

    CAS  PubMed  Google Scholar 

  23. Yamazaki, S. et al. Resetting central and peripheral circadian oscillators in transgenic rats. Science 288, 682–685 (2000)

    Article  ADS  CAS  Google Scholar 

  24. Panda, S. et al. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109, 307–320 (2002)

    Article  CAS  Google Scholar 

  25. Shigeyoshi, Y. et al. Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. Cell 91, 1043–1053 (1997)

    Article  CAS  Google Scholar 

  26. Zylka, M. J., Shearman, L. P., Weaver, D. R. & Reppert, S. M. Three period homologs in mammals: different light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain. Neuron 20, 1103–1110 (1998)

    Article  CAS  Google Scholar 

  27. Travnickova-Bendova, Z., Cermakian, N., Reppert, S. M. & Sassone-Corsi, P. Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity. Proc. Natl Acad. Sci. USA 99, 7728–7733 (2002)

    Article  ADS  CAS  Google Scholar 

  28. Hida, A. et al. The human and mouse Period 1 genes: five well-conserved E-boxes additively contribute the enhancement of mPer1 transcription. Genomics 65, 224–233 (2000)

    Article  CAS  Google Scholar 

  29. Sueyoshi, T. et al. The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J. Biol. Chem. 274, 6043–6046 (1999)

    Article  CAS  Google Scholar