Poonawalla or Poonawala is an Indian (Parsi/Dawoodi Bohra/Khoja) toponymic surname for someone from Pune (formerly Poona) in India. It may refer to:

• Adar Poonawalla, (born 1981), Indian businessman
• Cyrus S. Poonawalla, Indian businessman
• Ismail Poonawala (born 1937), Indian professor of Arabic
• Lila Poonawalla, (born 1944), Indian industrialist
• Natasha Poonawalla, (born 1981), Indian philanthropist
• Riaz Poonawala (born 1961), Indian cricketer

• Poona (disambiguation)