[proxy] pubmed.ncbi.nlm.nih.gov — ← back | site home | direct (HTTPS) ↗ | proxy home | ◑ dark◐ light

Molecular genetics of a biological clock in Drosophila - PubMed

T A Bargiello  1 , M W Young

Molecular genetics of a biological clock in Drosophila

T A Bargiello et al. Proc Natl Acad Sci U S A. 1984 Apr.

Abstract

Ninety kilobase pairs (kb) of DNA have been isolated from the 3B region of the X chromosome of Drosophila melanogaster. Previous cytogenetic analyses have placed a gene required for rhythmic behavior (per) in this chromosomal interval. Physical characterization of a series of chromosomal rearrangements altering per locus activity indicates that DNA affecting behavioral rhythms is found in a 7.1-kb HindIII fragment. A single 4.5-kb poly(A)(+) RNA is transcribed from this DNA in wild-type pupae and adult flies. The transcript is eliminated by a per mutant that retains some rhythmic activity, but this mutant substitutes two novel transcripts, 11.5 kb and 0.9 kb. It is suggested that the new poly(A)(+) transcripts provide residual per locus activity.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1971 Sep;68(9):2112-6 - PubMed
    1. Genetics. 1975 Apr;79(4):601-11 - PubMed
    1. Cell. 1978 Oct;15(2):687-701 - PubMed
    1. Genetics. 1972 May;71(1):139-56 - PubMed
    1. Chromosoma. 1972;36(4):391-412 - PubMed

LinkOut - more resources