ELF4 as a Central Gene in the Circadian Clock
Elsebeth Kolmos et al. Plant Signal Behav. 2007 Sep.
Abstract
The light-dark cycle of the environment serves as one of the major Zeitgebers in entrainment of the circadian clock. The circadian system consists of interconnected feedback loops in which the CCA1/LHY-TOC1 loop has a central position. Genetic analyses of the elf4 mutant suggested that it is a positive regulator of CCA1 and LHY expression. Recently, we refined the mode-of-action of ELF4 in entrainment of the clock, and here hypothesize that ELF4 expression is interlocked with the CCA1/LHY-TOC1 loop.
Keywords: CCA1; ELF4; LHY; TOC1; circadian clock; entrainment; feedback loop.
Figures
Comment on
-
ELF4 is required for oscillatory properties of the circadian clock.
McWatters HG, Kolmos E, Hall A, Doyle MR, Amasino RM, Gyula P, Nagy F, Millar AJ, Davis SJ. McWatters HG, et al. Plant Physiol. 2007 May;144(1):391-401. doi: 10.1104/pp.107.096206. Epub 2007 Mar 23. Plant Physiol. 2007. PMID: 17384164 Free PMC article.
References
-
- Schaffer R, Ramsay N, Samach A, Corden S, Putterill J, Carre IA, Coupland G. The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering. Cell. 1998;93:1219–1229. - PubMed
-
- Strayer C, Oyama T, Schultz TF, Raman R, Somers DE, Mas P, Panda S, Kreps JA, Kay SA. Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog. Science. 2000;289:768–771. - PubMed
-
- Wang ZY, Tobin EM. Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression. Cell. 1998;93:1207–1217. - PubMed
-
- Doyle MR, Davis SJ, Bastow RM, McWatters HG, Kozma-Bognar L, Nagy F, Millar AJ, Amasino RM. The ELF4 gene controls circadian rhythms and flowering time in Arabidopsis thaliana. Nature. 2002;419:74–77. - PubMed
LinkOut - more resources
Full Text Sources